PGCBL Alumni in the MLB
| # | Name | Pos. | PGCBL Year(s) | PGBL Team | MLB Team | MLB Debut |
| 1 | Shae Simmons | RHP | 2010 | Watertown Wizards | Atlanta Braves | 5/31/2014 |
| 2 | Luke Maile | C | 2010-11 | Amsterdam Mohawks | Tampa Bay Rays | 9/1/2015 |
| 3 | Tom Murphy | C | 2010 | Oneonta Outlaws | Colorado Rockies | 9/12/2015 |
| 4 | Carlos Asuaje | 2B | 2011 | Oneonta Outlaws | San Diego Padres | 9/21/2016 |
| 5 | Mark Leiter Jr | RHP | 2011-12 | Amsterdam Mohawks | Philadelphia Phillies | 4/28/2017 |
| 6 | Nick Pivetta | RHP | 2012 | Glens Falls Dragons | Philadelphia Phillies | 4/30/2017 |
| 7 | Jimmy Yacabonis | RHP | 2012 | Elmira Pioneers | Baltimore Orioles | 6/11/2017 |
| 8 | Tim Locastro | OF | 2013 | Newark Pilots | Los Angeles Dodgers | 9/29/2017 |
| 9 | Ryan Yarborough | LHP | 2011 | Utica Blue Sox | Tampa Bay Rays | 3/31/2018 |
| 10 | James Norwood | RHP | 2012 | Cooperstown | Chicago Cubs | 7/11/2018 |
| 11 | Ramon Laureano | OF | 2013 | Glens Falls Dragons | Oakland Athletics | 8/3/2018 |
| 12 | Trey Wingenter | RHP | 2013 | Amsterdam Mohawks | San Diego Padres | 8/7/2018 |
| 13 | Cedric Mullins | OF | 2014 | Utica Brewers | Baltimore Orioles | 8/10/2018 |
| 14 | John Means | LHP | 2012 | Mohawk Valley | Baltimore Orioles | 9/26/2018 |
| 15 | Matt Thaiss | C | 2013 | Watertown Rapids | Los Angeles Angels | 7/3/2019 |
| 16 | Chandler Shepherd | RHP | 2012 | Amsterdam Mohawks | Baltimore Orioles | 8/13/2019 |
| 17 | Tyler Rogers | RHP | 2010 | Mohawk Valley | San Francisco Giants | 8/27/2019 |
| 18 | Caleb Baragar | LHP | 2015 | Amsterdam Mohawks | San Francisco Giants | 7/25/2020 |
| 19 | John Nogowski | 1B | 2013 | Amsterdam Mohawks | St. Louis Cardinals | 8/16/2020 |
| 20 | Ian Anderson | RHP | 2016 | Amsterdam Mohawks | Atlanta Braves | 8/26/2020 |
| 21 | Ernie Clement | UTIL | 2014 | Albany Dutchmen | Cleveland Indians | 6/13/2021 |
| 22 | Tayler Saucedo | LHP | 2012 | Glens Falls Dragons | Toronto Blue Jays | 6/17/2021 |
| 23 | Ryan Dorow | INF | 2015 | Adirondack | Texas Rangers | 8/26/2021 |
| 24 | Zach Logue | LHP | 2015 | Amsterdam Mohawks | Oakland Athletics | 4/19/2022 |
| 25 | Sean Hjelle | RHP | 2016 | Elmira Pioneers | San Francisco Giants | 5/6/2022 |
| 26 | Jared Solomon | RHP | 2016 | Utica Blue Sox | Cincinnati Reds | 5/7/2022 |
| 27 | Matt Gage | LHP | 2012 | Amsterdam Mohawks | Toronto Blue Jays | 6/6/2022 |
| 28 | Charles Leblanc | INF | 2014 | Watertown Rams | Miami Marlins | 7/30/2022 |
| 29 | Louis Varland | RHP | 2017 | Utica Blue Sox | Minnesota Twins | 9/7/2022 |
| 30 | Gus Varland | RHP | 2016 | Utica Blue Sox | Milwaukee Brewers | 3/30/2023 |
| 31 | Tim Herrin | LHP | 2016 | Amsterdam Mohawks | Cleveland Guardians | 4/2/2023 |
| 32 | Joe La Sorsa | LHP | 2017 | Amsterdam Mohawks | Tampa Bay Rays | 5/29/2023 |
| 33 | Zach Remillard | INF | 2015 | Albany Dutchmen | Chicago White Sox | 6/17/2023 |
| 34 | Jordan Westburg | INF | 2018 | Elmira Pioneers | Baltimore Orioles | 6/26/2023 |
| 35 | Chris Vallimont | RHP | 2016 | Jamestown Tarp Skunks | Baltimore Orioles | 7/3/2023 |
| 36 | Andrew Saalfrank | LHP | 2017 | Amsterdam Mohawks | Arizona Diamondbacks | 9/5/2023 |
| 37 | Justin Foscue | INF | 2018 | Amsterdam Mohawks | Texas Rangers | 4/5/2024 |
| 38 | Matt Gorski | 1B | 2017 | Amsterdam Mohawks | Pittsburgh Pirates | 4/24/2025 |